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The Brain and Addiction

Why Does NIDA Study Addiction in Teens?

Screengrab of Brandon Thomas Lee and Dr. Volkow

Image by NIDA.

The actor Brandon Thomas Lee recently sat down with NIDA’s Director, Dr. Nora Volkow, for a virtual conversation about addiction, recovery, mental health, and how COVID-19 affects it all. One of Brandon’s questions was, “NIDA does a lot of research focused on teenage/young adult drug use in particular—why is that?” Watch her answer:

Your brain is who you are. It’s what allows you to think, breathe, move, speak, and feel. It’s just 3 pounds of gray-and-white matter that rests in your skull, and it is your own personal “mission control.”

The brain is always working, even when you’re sleeping. Information from your environment makes its way to the brain, which receives, processes, and integrates it so that you can survive and function under all sorts of changing circumstances and learn from experience. This information comes from both outside your body (like what your eyes see and skin feels) and inside (like your heart rate and body temperature).

The brain is made up of many parts that all work together as a team. Each of these different parts has a specific and important job to do. When drugs enter the brain, they interfere with its normal tasks and can eventually lead to changes in how well it works. Over time, drug use can lead to addiction, a devastating brain disease—when people can’t stop using drugs even when they really want to, and even after it causes terrible consequences to their health and other parts of their lives.

Drugs affect mostly three areas of the brain:

  • The brain stem is in charge of all the functions our body needs to stay alive—breathing, moving blood, and digesting food. It also links the brain with the spinal cord, which runs down the back and moves muscles and limbs. It also lets the brain know what’s happening to the body.
  • The limbic system links together a bunch of brain structures that control our emotional responses, such as feeling pleasure when we eat chocolate or kiss someone we love. The good feelings motivate us to repeat the behavior, which can be good because things like eating and love are critical to our lives.
  • The cerebral cortex is the mushroom-shaped outer part of the brain (the gray matter). In humans, it is so big that it makes up about three-fourths of the entire brain. It’s divided into four areas, called lobes, which control specific functions. Some areas process information from our senses, allowing us to see, feel, hear, and taste. The front part of the cortex, known as the frontal cortex or forebrain, is the thinking center. It powers our ability to think, plan, solve problems, and make decisions.

Is Addiction a Disease?

Experts say YES.

 

The National Institute on Drug Abuse (NIDA), the American Medical Association (AMA)  and the American Society of Addiction Medicine (ASAM) frame substance use disorder as a medical condition. 

Yet many continue to ask whether addiction is a disease, so we asked the country’s top expert on addiction, Dr. Nora Volkow, the Director of the National Institute on Drug Abuse (NIDA) at the National Institutes of Health (NIH).

“It’s actually been strange to me that people have a difficulty in understanding addiction as a disease, because a disease is basically described as damage to an organ or system that jeopardizes your wellbeing,” explains Dr. Volkow. “We now have clear cut evidence that certain circuits in the brain become dysfunctional when you are addicted to drugs.”

A Disease is Not a Moral Failing.

Stigma refers to when individuals are discriminated against, devalued, rejected or excluded as a result of belonging to a particular group. Addiction-related stigma prevents people who are struggling from reaching out for help and isolates families affected by addiction who fear being judged by their communities.  In 2018, 16 percent of individuals with a SUD did not seek treatment because they worried that it would have a negative impact on their employment; and approximately 15 percent felt it would impact their community’s view of them.

Fear and misunderstanding often lead to prejudice against people with substance use disorders, even among healthcare providers. It’s also one of the main reasons people don’t consider addiction a real health issue. These prejudices and biases leads to feelings of shame in those struggling and creates serious barriers to diagnosis and treatment.

Education around addiction and how to both prevent and treat the health condition is a critical step in improving our response nationwide. Misinformation about addiction can contribute to stigma which too often dissuades individuals with substance use disorders from seeking help.

 

Substance use activates the dopamine process in the survival center much more powerfully than natural rewards like food or sex. When repeated it can hijack the brain, making it think that the substance is the most important thing for survival. Over time, more and more of the substance is needed to activate the same level of reward, causing the brain’s circuits to become increasingly imbalanced–eroding a person’s self-control and ability to make sound decisions, while producing intense impulses to seek and use the substance.
 

This is what it means when scientists say that addiction is a brain disease. The good news – SUDs are preventable and treatable, and brain scans show that once an individual is in recovery, brain tissue can get better.

For more information, visit: https://www.addictionpolicy.org

Thanks to the National Institute on Drug Abuse (NIDA) for the science highlighted. https://www.drugabuse.gov/

 

VIDEO –  DRUGS: SHATTER THE MYTHS

Drugs are chemicals. When someone puts these chemicals into their body, either by smoking, injecting, inhaling, or eating them, they tap into the brain’s communication system and tamper with the way nerve cells normally send, receive, and process information. Different drugs—because of their chemical structures—work differently. We know there are at least two ways drugs work in the brain:

  • Imitating the brain’s natural chemical messengers
  • Overstimulating the “reward circuit” of the brain

Some drugs, like marijuana and heroin, have chemical structures that mimic a neurotransmitter that naturally occurs in our bodies. In fact, these drugs can “fool” our receptors, lock onto them, and activate the nerve cells. However, they don’t work the same way as a natural neurotransmitter, and the neurons wind up sending abnormal messages through the brain, which can cause problems both for our brains and our bodies.

Other drugs, such as cocaine and methamphetamine, cause nerve cells to release too much dopamine, a natural neurotransmitter, or prevent the normal recycling of dopamine. This leads to exaggerated messages in the brain, causing problems with communication channels. It’s like the difference between someone whispering in your ear versus someone shouting in a microphone.

VIDEO: MIND MATTERS – HOW DO DRUGS WORK ON THE BRAIN?

Source: National Institute on Drug Abuse

What if you could look into the future and see what your life would be like if you became addicted to drugs?

 

During this “Squad Vlog,” a few members of the popular YouTube comedy  group SMOSH were shocked and terrified when they got a personal, up-close look at what their lives would be like if they became addicted to methoxycodone and heroin.

Watch squad members – Courtney, Noah and Keith – talk face-to-face to their “future selves” about their lives and addiction.